Doxercalciferol: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. For patients with suspected hypersensitivity to calcitonin salmon, skin testing should be considered prior to treatment utilizing a dilute, sterile solution of Miacalcin injection. Prevention of acute bone loss due to sudden immobilisation such as in patients with recent osteoporotic fractures. Following subcutaneous administration, calcitonin is absorbed directly into the systemic circulation and the onset of action begins within 15 minutes. Vitamin D analogs can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Not known whether calcitonin is distributed into human milk. The risk for hypocalcemia and other disturbances of mineral metabolism may increase during coadministration. Give supplemental calcium and vitamin D if dietary intake is inadequate. To comment please, Comments on Medscape are moderated and should be professional in tone and on topic. The time to 90% potency (T90) ranged from 32.0 hours to 41.7 hours. It is usually used once a day or once every other day. IM injection preferred when injection volume >2 mL. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed. You will receive email when new content is published. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location one that is up and away and out of their sight and reach. Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Solutions for infusion should be prepared immediately before use in soft plastic PVC infusion bags. If the liquid is not clear and colourless, or contains any particles, or the ampoule is damaged, do not use the medicine. Calcitonin may be considered for women who can not or will not take more effective agents; do not prescribe in early menopause as benefit/efficacy has not been observed within the first 5 years of menopause onset. k_b Calcitonin is a calciotropic hormone, which inhibits bone resorption by a direct action on osteoclasts. * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name, Miacalcin (synthetic; with phenol 5 mg/mL). In severe or emergency cases, intravenous infusion with up to 10 IU/kg body weight in 500 ml 0.9% w/v sodium chloride solution may be administered over a period of at least 6 hours. Commenting is limited to medical professionals. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Before preparing a dose, look at the vial. Should symptoms of overdose appear, treatment should be symptomatic. For the treatment of hypercalcemia, calcium supplements should be avoided. Calcitonin (salmon, synthetic) . Nasal effects described as mild. Frequent monitoring of the clinical and laboratory response including the measurement of serum calcium is recommended especially in the early phases of treatment. Use multiple sites of injection when volume >2 mL. Periodic nasal examinations with visualization of nasal mucosa, turbinates, septum, and mucosal blood vessel status are recommended for patients receiving calcitonin nasal spray. The metabolites lack the specific biological activity of calcitonin. Your doctor, nurse, or pharmacist will show you how to administer the medication. endobj The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Resume the regular dosing schedule at the beginning of the next week. For the treatment of hypercalcemia, calcium supplements should be avoided. If the volume of the injection exceeds 2 mL, intramuscular injection is preferable and multiple injection sites should be used.Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.With chronic use, ensure adequate intake of calcium and vitamin D to reduce the risk of treatment-related hypocalcemia. Store unopened bottle under refrigeration at 2C to 8C; Once the pump has been activated, store at room temperature . 2-8C. Dispose of all empty syringes and vials as directed by your healthcare provider. If anaphylaxis or other severe hypersensitivity/allergic reactions occur, initiate appropriate treatment. In lactating animals given calcitonin, suppression of milk production has been observed. Because calcitonin is a peptide, the possibility of systemic allergic reactions exists and allergic-type reactions including isolated cases of anaphylactic shock have been reported in patients receiving calcitonin. If the volume of the injection exceeds 2 mL, the IM route is preferred and multiple injection sites should be used.Rotate sites of injection.Dispose of the used syringe and needle in an FDA-cleared sharps disposal container after use. The possibility of antibody formation should be considered in any patient with an initial response to Miacalcin injection who later stops responding to treatment. Patients must therefore be warned that these effects may occur, in which case they should not drive or use machines. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. [27980] [52559] [57624], Use calcitonin with caution during breast-feeding. Copyright, 2023. For additional instructions see sections 6.3 and 6.6. Compared to younger adults, the incidence of nasal adverse events (rhinitis, irritation, erythema, and excoriation) was higher in patients over 65 years of age, particularly those over the age of 75 years. [0 /XYZ 69.5999999 For the treatment of hypercalcemia, vitamin D preparations should be avoided. For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. For the treatment of hypercalcemia, vitamin D preparations should be avoided. Inhibits lactation in animals. The U.S. Pharmacopeia's definition of room temperature (20-25 degrees C [68-77 degrees F]) was used for this review. Sub-Q injection preferred for patient self-administration. . /Pattern << Known hypersensitivity to calcitonin salmon. Activity of calcitonin salmon expressed in terms of International Units (units). The pharmacological properties of the synthetic and recombinant peptides have been demonstrated to be qualitatively and quantitatively equivalent. Available for Android and iOS devices. Appears to be rapidly metabolized to smaller inactive fragments in kidney, blood, and peripheral tissues. Minimum effective dosage not established; 100 units every other day may be effective in preserving vertebral BMD. Reserve use for patients that are more than 5 years postmenopause in whom alternative treatments are not suitable (e.g., patients for whom other therapies are contraindicated or for patients who are intolerant or unwilling to use other therapies). For the treatment of hypercalcemia, vitamin D preparations should be avoided. Maintenance: 50 units (0.25 mL) daily or every other day; higher dosage (100 units daily) appropriate in patients with serious deformity or neurologic involvement. Possibility of hypocalcemic tetany following parenteral administration; have calcium injection readily available, particularly during first several doses of parenteral calcitonin. Higher blood levels may be associated with increased incidence of nausea and vomiting. Calcitonin is given parenterally (preferably by subcutaneous or intramuscular injection) or intranasally since calcitonin is destroyed in the GI tract. endobj ;JrhxKXl]qXUp&t\eEj(Qf`9tG&*3?b6Ed!.DSO1^y6lh{\65 {5;x=FSNu'J+T;!B a0LC/%(1 Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. It works by preventing bone breakdown and increasing bone density (thickness). The absence of mineralisation defect with calcitonin has been demonstrated by bone histomorphometric studies both in man and in animals. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. endstream endobj startxref If your usual dose is one dose per day, use the missed dose if you remember it during the same day. Brand names: Fortical, Miacalcin >> Start typing to retrieve search suggestions. It may also be used to prevent bone loss in women with postmenopausal osteoporosis and to treat hypercalcemia (too much calcium in the blood). Inject into a large muscle. Adverse drug reactions from multiple sources including clinical trials and post-marketing experience are listed by MedDRA system organ class. Vitamin D analogs: (Moderate) Calcitonin is given to hypercalcemic patients to reduce serum calcium concentrations. Administer dose by placing nozzle in nostril with head in upright position and firmly depressing pump toward bottle. >> Miacalcin Injection is indicated for the treatment of postmenopausal osteoporosis in females greater than 5 years postmenopause with low bone mass relative to healthy premenopausal females. Keep all supplies in a clean, dry place and out of reach of children. >> 8 0 obj However, you should not flush this medication down the toilet. Calcitonin may cause fatigue, dizziness and visual disturbances (see section 4.8) which may impair the patient's reaction. >> URL of this page: https://medlineplus.gov/druginfo/meds/a682788.html. Calcitonin injection is used to treat Paget's disease of the bone. VA class: HS900 For the treatment of osteoporosis adequate intake of calcium salts are necessary in conjunction with calcitonin. Your doctor may order certain lab tests to check your body's response to calcitonin salmon. Then, continue a regular dosing schedule of every other day from that point. endobj Calcium salts, including calcium carbonate, can elevate serum calcium concentrations and antagonize the effects of the calcitonin for this condition. Treatment of postmenopausal osteoporosis in women >5 years postmenopause. Periodic examinations of urine sediment are recommended in patients receiving long-term parenteral therapy. In animals, salmon calcitonin has been shown to decrease lactation and to be excreted in milk (see section 5.3). We comply with the HONcode standard for trustworthy health information. endobj cool to room temperature. For the treatment of hypercalcemia, calcium supplements should be avoided. These trials demonstrated an increase in the absolute risk of cancer occurrence for patients treated with calcitonin compared to placebo which varied between 0.7% and 2.4% with long term therapy. 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