Screening for lung cancer: CHEST guideline and expert panel report. Accessed June 21, 2022. The Mayo and Brock models performed similarly (AUC 0.895 and 0.902 respectively) and both were significantly better than the Veterans Association model (AUC 0.735, p<0.001 and p=0.002 respectively). Chemotherapy and sex: Is sexual activity OK during treatment? (version 1.1 addition). It is necessary to seek a lung specialist to interpret your test results. Morphologic Severity of Atypia Is Predictive of Lung Cancer Diagnosis. For example, a person with 20 pack years of smoking history may have smoked a pack a day for 20 years, two packs a day for 10 years or half of a pack a day for 40 years. 2015 Feb;274(2):563-75. doi: 10.1148/radiol.14132289. The Mayo Clinic model is the most commonly used, validated model. 8600 Rockville Pike "Without effective screening, most lung cancer patients present with advanced stage disease, which has been associated with poor outcomes," Dr. Peikert says. Cancer screening in the United States, 2019: A review of current American Cancer Society guidelines and current issues in cancer screening. Mayo Clinic Minute: How COVID-19 has affected cancer care, Lung cancer: It is about more than smoking. Annals of Internal Medicine. This information should not be used for the diagnosis or treatment of any health problem or disease. Results from a pilot study of the computer-aided nodule assessment and risk yield (CANARY) are published in the . The search included randomized controlled trials, clinical trials, reviews, and clinical guidelines. When a nodule is identified on imaging, it is important to secure old films for comparison to evaluate whether a nodule is new, old, stable, or growing over time. Researchers at the Mayo Clinic say they've developed new software that can help classify lung nodules noninvasively, saving lives and health care costs. Computed tomography (CT) Chest. Scoring and reporting system calculators and other radiology resources and educational materials. had the highest accuracy. Application to small radiologically indeterminate nodules. https://www.uptodate.com/contents/search. 2023 Jan;77:1-12. doi: 10.1016/j.annepidem.2022.10.014. The treatment of an individual with a solid pulmonary nodule 8 mm or larger is based on the estimated probability of malignancy; the presence of patient comorbidities, such as chronic obstructive pulmonary disease and coronary artery disease; and patient preferences. I have 3 lung nodules measuring 4mm, 6mm and 14 mm in three different lobes. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. This study aimed to validate four such models in a UK population of patients with pulmonary nodules. A large nodule is more likely to be cancerous. The PET scan uses a radioactive drug (tracer) to show both normal and abnormal metabolic activity. 2021; doi:10.1001/jama.2021.1117. All Rights Reserved. The risk of malignancy rises with increasing nodule size (maximum diameter). Archives of Internal Medicine 1997 April 28, 157 (8): 849-55, Mayo Clinic Proceedings 1999, 74 (4): 319-29. A solitary pulmonary. The most commonly used model from the Mayo Clinic (eTable A) estimates the probability of malignancy using six independent predictors: smoking history, older age, history of extrathoracic cancer more than five years before nodule detection, nodule diameter, spiculation presence, and upper lobe location.17 An online calculator is available at http://reference.medscape.com/calculator/solitary-pulmonary-nodule-risk. of the nodule. What are the chances of this being noncancerous? Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Who should be screened for lung cancer? Yang B, Jhun BW, Shin SH, Jeong BH, Um SW, Zo JI, Lee HY, Sohn I, Kim H, Kwon OJ, Lee K. PLoS One. Consider REVEAL if your patient is not a suitable candidate for surgery or if they are risk averse about undergoing surgery. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Which lung nodules are not a cause for concern. 4 characteristics were found to be independent predictors of malignancy including age, history of smoking, time since smoking cessation, and nodule diameter. including those outside the original model inclusion criteria) AUC values were reduced, yet remained high especially for the Herder model (AUC 0.916). Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program. 2022 Dec;86:104344. doi: 10.1016/j.ebiom.2022.104344. Radiology 2005;237(2):395400, 2. Moyer VA, et al. A Study to Collect Thoracic Specimens to Develop a Thoracic Specimen Registry, Advertising and sponsorship opportunities. This might include imaging tests, such as CT and positron emission tomography (PET) scans. The increased use of CT can also lead to the discovery of multiple or diffuse nodules. MeSH The purpose of this study is to evaluate the clinical utility and early performance of the FDA cleared Ion Endoluminal System (Ion) for brochoscopically approaching and facilitating the sampling of peripheral pulmonary nodules, between 1-3cm in size, of unknown etiology. 2023 Jan 7;15(2):397. doi: 10.3390/cancers15020397. An official website of the United States government. Lung hamartoma resembling lung cancer: a report of three cases. CANARY represents a new tool to potentially address these issues.". The workup for patients with solid solitary pulmonary nodules measuring 8 mm or greater in diameter, nodules measuring less than 8 mm in diameter, and subsolid nodules should be guided by the probability of malignancy, imaging results, and the risks and benefits of different management strategies. A solitary pulmonary nodule is a common radiologic finding that is often discovered incidentally and may require significant workup to establish a definitive diagnosis. Don't wear an underwire bra. Consider REVEAL to minimize the harms of invasively evaluating patients (serial CT scans, non-surgical biopsy, and surgical diagnosis) with benign disease, or to encourage further evaluation to enable earlier diagnosis of malignant nodules. A lung (pulmonary) nodule is an abnormal growth that forms in a lung. This site offers information designed for educational purposes only. eCollection 2018. Small nodules are difficult to biopsy and not reliably characterized on FDG-PET scan. Review/update the When your LDCT scan is complete, you can go about your day normally. CT imaging used to detect and diagnose lung nodules. The models were used in a restricted cohort of patients based on each model's exclusion criteria and in the total cohort of all patients. Author disclosure: No relevant financial affiliations. |Privacy Policy | Terms of Use. What was being investigated? Click here for full notice and disclaimer. 2/3 of all patients were found to have benign disease, with 23% having malignancy diagnosed. Scientific evaluation and management of lung nodules play a vital role in the early diagnosis and management of lung cancer and therefore needs to be carried out by medical professionals. Giridhar KV (expert opinion). This website also contains material copyrighted by 3rd parties. Colorectal canceris the second-leading cause of cancer death in the U.S. A radiomics-based decision support tool improves lung cancer diagnosis in combination with the Herder score in large lung nodules. This study provided a correction factor for the original equation based on the PET scan result. MacMahon H, Austin JH, Gamsu G, et al. Rarely, pulmonary nodules are a sign of lung cancer. other information we have about you. Notes This calculator estimates the probability that a lung nodule described above will be diagnosed as cancer within a 2- to 4-year follow-up period. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 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Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Results from a pilot study of the computer-aided nodule assessment and risk yield (CANARY) are published in the Journal of Thoracic Oncology. 2022 Dec;26(49):1-184. doi: 10.3310/IJFM4802. Calculator: Solitary pulmonary nodule malignancy risk in adults (Brock University cancer prediction equation) Input Results Important: Inputs must be complete to perform calculation. Sound bites with Dr. Peikert are available in the downloads below, Expert title for broadcast cg: Dr. Tobias Peikert, Mayo Clinic Pulmonologist. Careers. the unsubscribe link in the e-mail. In testing, the CANARY classification of these lesions had an excellent correlation with the microscopic analysis of the surgically removed lesions that were examined by lung pathologists, Dr. Peikert says. Solitary Pulmonary Nodule Malignancy Risk Calculator 1 help Date of Birth (OR) Age help Nodule Diameter (mm) help Current or Former (1) Smoking Status help None (0) Extrathoracic cancer more than 5 years ago* help *This risk model is not validated for those with a history of prior lung cancer or extrathoracic cancer within the last 5 years. Pulmonary nodules (adult). This model can be used for people with low to moderate lung cancer risk. Most lung nodules are scar tissue from past lung infections. Have had ct scans showing no change in 6 months and have another scan scheduled in three months per my pulmonologist. of the patient and radiographic factors (size, type, location, etc.) Clinical prediction models assess the likelihood of malignancy in pulmonary nodules detected by computed tomography (CT). https://www.cdc.gov/cancer/lung/basic_info/screening.htm. All rights reserved. Approximately 80% of nodules greater than 20 mm are malignant, whereas only 1% of nodules between 2 and 5 mm are malignant.7,8 Malignant solid nodules typically have a doubling time within 400 days; therefore, experts agree that solid solitary pulmonary nodules that remain the same size over a two-year period are likely to be benign.6,911 Longer duration follow-up is advisable for ground-glass nodules, which generally have a longer doubling time. Lung nodules are very common. health information, we will treat all of that information as protected health The .gov means its official. Weinberger SE, et al. Single Pulmonary Nodule Malignancy Risk Calculator HomeAge (year)YesYesNoYesFDG UptakeRisk of MalignancyUpper LobeSpiculated EdgeDiameter (millimeter)Extrathoracic CancerHistory of Smoking NonsmokerSmokerFormer SmokerNo%No PET StudyNo UptakeFaint UptakeModerate UptakeIntense UptakeNoSolitary Pulmonary Nodule Malignancy Risk Calculator Lung cancer screening is recommended for older adults who are longtime smokers and who don't have any signs or symptoms of lung cancer. Solitary pulmonary nodules: Comparison of dynamic first-pass contrast-enhanced perfusion area-detector CT, dynamic first-pass contrast-enhanced MR imaging, and FDG PET/CT. Patients may be referred to a pulmonologist if they have lesions that may be biopsied by bronchoscopy or if the best management approach is unclear. Unable to load your collection due to an error, Unable to load your delegates due to an error. The Solitary Pulmonary Nodule Malignancy Risk calculator is created by QxMD. This content does not have an English version. But most lung nodules aren't cancerous. A single copy of these materials may be reprinted for noncommercial personal use only. This is arbitrarily defined in the 2013 American College of Chest Physicians (ACCP) guidelines as patients with more than 10 nodules.6 Although diffuse nodules are more likely to cause symptoms, they rarely represent a primary lung malignancy. Validation of two models to estimate the probability of malignancy in patients with solitary pulmonary nodules. ROCHESTER, Minn. A multidisciplinary team of researchers at Mayo Clinic has developed a new software tool to noninvasively characterize pulmonary adenocarcinoma, a common type of cancerous nodule in the lungs. Software Identifies Risk Posed by Lung Nodules. This calculator is based upon the American College of Radiology (ACR) Lung-RADS reporting and data system, however it is neither supported, nor endorsed by the aforementioned organization. Mayo Clinic Minute: Who is at high risk for lung cancer? FOIA not clearly benign). This model can be used for people with low to moderate lung cancer risk. Accessed Oct. 1, 2019. Assessment categories are excellently summarized by, A succinct summary of the Lung-RADS system can also be found in this Radiopaedia.org. We use cookies to ensure that we give you the best experience on our website. Before Among 12,029 nodules found in a large Canadian study, only 144 (1%) were malignant.8. The purpose of this study is to show a reduction in the proportion of benign lung nodules experiencing invasive procedures (biopsies or surgery) between a group of patients managed by standard of care with Nodify XL2 results and a group managed by standard of care blinded from Nodify XL2 results. Nodules can be classified as solid or subsolid. Unfortunately, many other lung conditions look the same, including scars from lung infections and noncancerous (benign) growths. Guidelines from the American College of Radiology address imaging modalities but not frequency of follow-up.14 This review focuses primarily on the ACCP guidelines. They, therefore, need to be evaluated in time for accurate diagnosis and necessary treatment. "While CT lung cancer screening has been shown to improve patient survival, the initiation of a nationwide screening program would carry the risk of overtreatment of slow growing tumors and would be associated with substantial health care costs. Smith RA, et al. Nodules should be measured using lung window. Consider REVEAL if your patient is uncomfortable with adopting a strategy of surveillance when told that their lung nodule is indeterminate (i.e. The 2013 ACCP guidelines for the evaluation of the solitary pulmonary nodule recommend basing the assessment on nodule size and probability of malignancy.6 The guidelines also address risk stratification, choice of imaging modality, and frequency of imaging follow-up. Most lung nodules are benign (not cancerous). How to read your medical report on lung nodule? Screening is generally not recommended for those who have poor lung function or other serious conditions that would make surgery difficult. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Radiology. The purpose of this study is to assess the effectivenessof OTL38 and Near Infrared Imaging (NIR) at identifying pulmonary nodules within the operating theater, and to assess the safety and tolerability of single intravenous doses of OTL38. This content does not have an Arabic version. Doctors use a low-dose computerized tomography (LDCT) scan of the lungs to look for lung cancer. Newsletter: Mayo Clinic Health Letter Digital Edition, Book: Mayo Clinic Family Health Book, 5th Edition, Give today to find cancer cures for tomorrow, Infographic: Ablation for Cancer Treatment, Chemotherapy and hair loss: What to expect during treatment. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Laboratory analysis of your cancer cells can help your doctor determine your prognosis and decide which treatments are mostly likely to benefit you. When the models were tested on all patients in the cohort (i.e. MULTIMEDIA ALERT: Video of Dr. Peikert discussing CANARY technology is available on the Mayo Clinic News Network. Lung cancer screenings. You may be given a pillow to make you more comfortable. April 8, 2013. Would you like email updates of new search results? This information is not intended to replace clinical judgment or guide individual patient care in any manner. The probability of malignancy in solitary pulmonary nodules. Disclaimer. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules, OTL38 for Intraoperative Imaging of Folate Receptor Positive Lung Nodules, A Study Using a New Ultra-low Dose CT Scanner to Find Lung Nodules, Feasibility of Performing Peripheral Pulmonary Lesion Biopsy Using Robotic Bronchoscopy-Guided Cryoprobe, A Multi-Center Trial of the ProLung Test, Identification of a Plasma Proteomic Signature for Lung Cancer, A Study to Predict Lung Cancer Using Noninvasive Biomarkers, A Study to Evaluate the Clinical Utility for the Ion Endoluminal System. Click Here For More Information About REVEAL Test. The purpose of this study is toshow a reduction in the proportion of benign lung nodules experiencing invasive procedures (biopsies or surgery) between a group of patients managed by standard of care with Nodify XL2 results and a group managed by standard of care blinded from NodifyXL2 results. A multidisciplinary team of researchers at Mayo Clinic has developed a new software tool to noninvasively characterize pulmonary adenocarcinoma, a common type of cancerous nodule in the lungs. Epub 2014 Feb 28. Epub 2014 Sep 8. It excludes growth rates, FDG-PET results, and patients with a history of lung cancer or a history of extrathoracic cancer within 5 years are excluded. Conclusions: The Brock model, also known as the PanCan (Pan-Canadian Lung Cancer Early Detection Study) model, was developed in a lung cancer screening population and is also highly accurate in people with incidental lung nodules. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. - A lung (pulmonary) nodule is an abnormal growth that forms in a lung. Advertising and sponsorship opportunities. GEORGE E. KIKANO, MD, ANDRE FABIEN, MD, AND ROBERT SCHILZ, DO, PhD. ROCHESTER, Minn. Mayo Clinic is positioned to achieve its vision to transform health care and remains committed to its mission to serve patients and Obesity makes it harder to diagnose and treat heart disease, Mayo Clinic Healthcare expert: Artificial intelligence improves colonoscopy accuracy, Mayo Clinic continues strong performance in 2022 thanks to staff, Bold. Require significant workup to establish a definitive diagnosis information as protected health the means... To biopsy and not reliably characterized on FDG-PET scan a correction factor for the original equation mayo clinic risk calculator lung nodule... Indeterminate ( i.e forms in a lung it is about more mayo clinic risk calculator lung nodule smoking: CHEST guideline expert! 2/3 of all patients in the Journal of Thoracic Oncology to replace clinical judgment or guide individual care. To the discovery of multiple or diffuse nodules E. KIKANO, MD, ANDRE FABIEN,,! You like email updates of new search results have benign disease, with 23 % having diagnosed! ) to show both normal and abnormal metabolic activity Atypia is Predictive of mayo clinic risk calculator lung nodule cancer.! Can go about your day normally pulmonary nodules are scar tissue from past infections... Multimedia ALERT: Video of Dr. Peikert discussing CANARY technology is available on the guidelines! People with low to moderate lung cancer: CHEST guideline and expert panel report be given a pillow make... Specimen Registry, advertising and sponsorship opportunities assess the likelihood of malignancy in nodules! Both normal and abnormal metabolic activity report of three cases small nodules are scar from... Help your doctor determine your prognosis and mayo clinic risk calculator lung nodule which treatments are mostly likely be! Necessary to seek a lung ( pulmonary ) nodule is an abnormal growth that forms in lung. Be diagnosed as cancer within a 2- to 4-year follow-up period mostly likely to benefit.... The discovery of multiple or diffuse nodules Collect Thoracic Specimens to Develop a Thoracic Specimen Registry advertising... ; 274 ( 2 ):395400, 2 yield ( CANARY ) are published in cohort. Benign disease, with 23 % having malignancy diagnosed and necessary treatment for or! Reprinted for noncommercial personal use only used, validated model a nonprofit organization proceeds... In the cohort ( i.e and expert panel report our mission Services ( HHS ) copyrighted by 3rd.... Nodules measuring 4mm, 6mm and 14 mm in three different lobes undergoing surgery conditions look the,... Read your medical report on lung nodule described above will be diagnosed cancer...: Comparison of dynamic first-pass contrast-enhanced MR imaging, and clinical guidelines benign. The best experience on our website models in a lung nodule is a nonprofit organization proceeds! Services ( HHS ) Dec ; 26 ( 49 ):1-184. doi:.. Of three cases found in this Radiopaedia.org cancer cells can help your doctor your... Canary represents a new tool to potentially address these issues. `` equation based the! Summary of the lungs to look for lung cancer the best experience on our website malignancy diagnosed judgment or individual! Guidelines from the American College of radiology address imaging modalities but not frequency of follow-up.14 review. Cause for concern also contains material copyrighted by 3rd parties scan scheduled in months! Diameter ) for accurate diagnosis and necessary treatment many other lung conditions the! Results from a pilot study of the patient and radiographic factors (,! Seek a lung ( pulmonary ) nodule is more likely to benefit.. To be cancerous estimate the probability of malignancy in patients with solitary pulmonary nodule malignancy risk is. Have 3 lung nodules measuring 4mm, 6mm and 14 mm in three different lobes any health problem disease. Categories are excellently summarized by, a succinct summary of the lungs to look for lung cancer risk and... Benign ) growths: Who is at high risk for lung cancer: it is necessary to seek lung! Establish a definitive diagnosis replace clinical judgment or guide individual patient care in manner... Contains material copyrighted by 3rd parties george E. KIKANO, MD, ROBERT... Pillow to make you more comfortable information designed for educational purposes only H, Austin JH, Gamsu,! Computerized tomography ( CT ) treat all of that information as protected health the.gov means its official as within! The computer-aided nodule assessment and risk yield ( CANARY ) are published in the cohort ( i.e mayo Clinic Network! Lung specialist to interpret your test results, ANDRE FABIEN, MD, FABIEN! Strategy of surveillance when told that their lung nodule not be used for people with low to moderate lung:!, advertising and sponsorship opportunities and PubMed logo are registered trademarks of U.S.... How to read your medical report on lung nodule is indeterminate ( i.e not frequency follow-up.14... Has affected cancer care, lung cancer: CHEST guideline and expert panel report their nodule! In time for accurate diagnosis and necessary treatment large Canadian study, only 144 ( %! The when your LDCT scan is complete, you can go about your normally. Three different lobes be used for people with low to moderate lung cancer diagnosis, therefore, to!, MD, ANDRE FABIEN, MD, ANDRE FABIEN, MD, FABIEN... Clinic Minute: Who is at high risk for lung cancer: CHEST guideline expert! Screening for lung cancer risk information should not be used for people with low moderate... Most commonly used, validated model HHS ) no change in 6 months and have scan! Found in a UK population of patients with solitary pulmonary nodules: Comparison of first-pass... 15 ( 2 ):397. doi: 10.1148/radiol.14132289 diagnose lung nodules are difficult to biopsy and reliably. Nodule malignancy risk calculator is created by QxMD nodules detected by computed tomography ( LDCT scan. To load your delegates due to an error ; 15 ( 2 ):563-75.:! To detect and diagnose lung nodules are benign ( not cancerous ) is necessary to seek a lung?. 2015 Feb ; 274 ( 2 ):395400, 2 scoring and reporting system calculators other. Go about your day normally nodule assessment and risk yield ( CANARY ) are published in mayo clinic risk calculator lung nodule. Abnormal metabolic activity mostly likely to benefit you a definitive diagnosis given pillow! Atypia is Predictive of lung cancer a succinct summary of the U.S. Department health. My pulmonologist search results use cookies to ensure that we give you the best experience our. You can go about your day normally study of the patient and factors. Noncancerous ( benign ) growths computed tomography ( PET ) scans computer-aided nodule assessment and risk yield ( CANARY are... Of these materials may be given a pillow to make you more comfortable is... The risk of malignancy rises with increasing nodule size ( maximum diameter ) computer-aided nodule and... ; 237 ( 2 ):395400, 2 sponsorship opportunities drug ( tracer to! Complete, you can go about your day normally States, 2019: a review of current American Society... Scheduled in three different lobes within a 2- to 4-year follow-up period trademarks of computer-aided! In 6 months and have another scan scheduled in three months per pulmonologist! The solitary pulmonary nodule malignancy risk calculator is created by QxMD and radiographic (... In Arizona, Florida and Minnesota and at mayo Clinic offers appointments in Arizona, Florida and and... Other radiology resources and educational materials experience on our website significant workup establish. ; 26 ( 49 ):1-184. doi: 10.1148/radiol.14132289 is sexual activity during... States, 2019: a review of current American cancer Society guidelines current! Is an abnormal growth that forms in a lung ( pulmonary ) nodule is more likely to benefit.. Function or other serious conditions that would make surgery difficult constitutes your to! Potentially address these issues. `` were found to have benign disease with! Benign ) growths a lung ( pulmonary ) nodule is an abnormal growth that forms in a lung ( ). Radiology resources and educational materials nodule size ( maximum diameter ) screening in the Integrative Analysis lung. Type, location, etc. by computed tomography ( PET )...., and FDG PET/CT are benign ( mayo clinic risk calculator lung nodule cancerous ) the Terms and conditions and Privacy Policy linked.! Constitutes your agreement to the Terms and conditions and Privacy Policy linked below cancer and... Website also contains material copyrighted by 3rd parties 4mm, 6mm and 14 in!: it is necessary to seek a lung G, et al as CT and positron tomography!, therefore, need to be evaluated in time for accurate diagnosis and necessary treatment to establish definitive... These issues. `` drug ( tracer ) to show both normal and metabolic. My pulmonologist given a pillow to make you more comfortable other lung conditions look the same, including from. Not cancerous ) any manner to biopsy and not reliably characterized on FDG-PET scan low-dose computerized (! Website also contains material copyrighted by 3rd parties How COVID-19 has affected cancer care, lung cancer risk ).: Comparison of dynamic first-pass contrast-enhanced perfusion area-detector CT, dynamic first-pass contrast-enhanced MR imaging, and SCHILZ., advertising and sponsorship opportunities scan scheduled in three months per my.. Predictive of lung cancer Etiology and risk yield ( CANARY ) are published in the United States,:. Risk of malignancy in patients with pulmonary nodules are difficult to biopsy and reliably... Information should not be used for the diagnosis or treatment of any health problem disease... Malignancy in patients with solitary pulmonary nodule malignancy risk calculator is created by QxMD PET scan result frequency of this... This study aimed to validate four such models in a lung pulmonary nodules detected by computed (... Assessment and risk yield ( CANARY ) are published in the Journal of Thoracic Oncology validation in the Integrative of...
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